In keeping with the title, the chapters of this report describe the mechanisms of chemical-associated autoimmune responses, chemical/physical agents and autoimmunity, and non-chemical factors in autoimmunity, as well as risk assessment. Initial sections describe intrinsic factors in autoimmunity, the clinical expression of human autoimmune disease, and epidemiology. Both animal models and human testing are described. This report was sponsored by the United Nations Environment Programme, the International Labour Organization, and the World Health Organization. There is a lengthy list of references and a glossary, but no index. The text is also available as a pdf file at www.who.int/entity/ipcs/publications/ehc/ehc236.pdf Annotation 2007 Book News, Inc., Portland, OR (booknews.com)